IVCC is committed to discovering and developing novel insecticides for vector control tools, including insecticide-treated nets (ITNs), indoor residual sprays (IRS), and emerging technologies like and spatial emanators.
Project overview:
Our approach begins with identifying and evaluating promising compounds, assessing their efficacy against both susceptible and resistant mosquito strains. In addition to effectiveness, we assess product safety, cost of goods (considering likely use rates), mode of action, physical-chemical properties, freedom to operate, and fit for purpose with tools under development.
Active ingredient screening (repurposed and novel)
Alongside our industry partners, we screen commercial insecticides from agricultural and public health applications to identify repurposed compounds that could be rapidly developed for vector control. Working with the Liverpool Insecticide Testing Establishment (LITE), we have screened over 80 active ingredients, with three now advancing into product development.
Once lead candidates have been identified, they will become part of a wider portfolio of existing and repurposed chemistry for use in vector control tools. Insecticide Resistance Management (IRM) is key if these novel AIs are going to be sustainable in the market, and successful in combating insecticide resistance.
The Global Health Priority Box
The Global Health Priority Box – provides scientists with free access to 240 compounds targeting infectious diseases and vectors. It includes compounds for malaria, neglected diseases, and vector control research. In partnership with Medicines for Malaria Venture (MMV).
