ATSB® project partners* are pleased to announce that the first of three large scale epidemiological studies have begun to support the opening of a new product class for vector control interventions which address the growing problem of outdoor biting mosquitoes.

Zambia was the first country to start this trial in November 2021 with more than 40,000 bait stations deployed in 35 clusters. A total of 2,450 children aged 1 to 14 years old are enrolled in this study which is expected to last two years.

Two similar studies will be conducted in Kenya and Mali starting in March and April 2022 which together with entomological, social science and cost-effectiveness analysis will constitute the data package which will be submitted to WHO to open the new product class and to regulatory authorities to seek approval for market deployment in sub-Saharan countries.

This is a major achievement following a decade of research and product development. In 2016 and 2017 large-scale proof-of-concept studies were conducted in Mali[1], which demonstrated a significant impact on mosquito density and survival. Since then, a manufacturing platform was established to produce enough ATSB® stations with an agreed specification and quality. Modelling based on preliminary results anticipates that a 2-3% daily feeding rate on ATSB® would lead to a 30% decrease in malaria incidence.

A large campaign of entomological trials was subsequently performed in Zambia, Kenya and Mali in 2020 and 2021 to assess daily feeding rates across diverse ecological settings and to confirm the ATSB bait station resilience when deployed in real field conditions, for example, when, exposed to rain, dust, wind and temperature variations.

The Bill & Melinda Gates Foundation, UK Aid and the Swiss Agency for Development and Cooperation (SDC) are co-funding the entomological and epidemiological impact evaluation of this new vector control tool.

How ATSB works

A significant trend that has emerged in recent years is the growing incidence of outdoor biting.  Mosquitoes are evolving, leading to biting earlier in the evening before people enter their houses to sleep under bed nets or biting after sunrise.  Changes in species composition and behaviour have also been observed towards the dominance of outdoor biting and resting species. This trend is also being exacerbated by changes in human behaviour, with more time being spent outside structures particularly early evening when vulnerable to outdoor biting, often driven by increased accessibility to electricity.

Female mosquitoes take blood meals for egg production, but mosquitoes from both genders must feed regularly and frequently on sugar for energy to survive. Common sources of sugar meals include plant tissue and floral nectar. Two ATSB® bait stations are placed on exterior walls of houses and lures the mosquitoes with an attractant which contains a sugar source laced with an insecticide.

Whilst vector control tools such as bed nets and indoor residual sprays have traditionally targeted indoor biting mosquitoes, there remains a significant gap in the malaria eradication toolbox for outdoor biting interventions.  ATSB®s have the potential to fill this important gap.

Note to Editors:

* Project partners are: Westham Co, IVCC, PATH, Liverpool School of Tropical Medicine, University of Science, Technique and Technology of Bamako.

[1] https://malariajournal.biomedcentral.com/articles/10.1186/s12936-020-3132-0

Featured image: ATSB station secured on the exterior wall of a structure. Credit PATH.

Led by IVCC, the New Nets Project is piloting new tools to strengthen the insecticide-treated net (ITN) market. Project partner Molly Robertson of PATH has written a blog following the publication of interim analyses that illustrates the potential effectiveness of new ITN types. Read more here.

IVCC’s Annual report for 2021 has been published. The report showcases IVCC’s work to facilitate innovative approaches to preventing vector-borne diseases and tackle the growing threat of insecticide resistance. With activities across the globe and spanning research and development and market access, we are accelerating the process from innovation to impact. The report is a reminder of the importance of collaborative working and the progress laid out in it is testament, too, to the commitment of our partners from industry, academia, the public sector and advocacy. We are grateful for the support of all of our funders, who make life-saving vector control possible.

The IVCC Annual Report 2022-2023 has been published.

The report showcases IVCC’s work to facilitate innovative approaches to preventing vector-borne diseases and tackle the growing threat of insecticide resistance. With activities across the globe and spanning research and development and market access, we are accelerating the process from innovation to impact.

The report is a reminder of the importance of collaborative working and the progress laid out in it is testament, too, to the commitment of our partners from industry, academia, the public sector, and advocacy. We are grateful for the support of all our funders, who make life-saving vector control possible.

Earlier in 2023 IVCC embarked upon a strategic review to assess and realign priorities to ensure that we are focusing on the unmet needs that will have the most significant impact against vector-borne disease. The annual report outlines IVCC’s strategic priorities going forward.

Another highlight is a section on climate change and the dramatic impact it is having on vector-borne disease transmission, demanding new policies, tools and approaches.

“At this pivotal time for global health, I call upon the wider global community to ensure that, as IVCC and its partnerships continue with their missions, appropriate political will and funding, facilitates and strengthens our collective efforts to eradicate malaria and the neglected tropical diseases that afflict the most vulnerable members of society.”

Sherwin Charles, Chair, Board of Trustees, IVCC.

For more information or to request a physical copy please provide your full name and postal address to Laura Roberts on laura.roberts@ivcc.com.

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Given the breadth of vector control-related literature, we are unable to include all relevant work. These updates are intended to focus primarily on Anopheles biology and a subset of control topics with global relevance.

Any views expressed in the updates do not necessarily reflect the views or opinions of IVCC. In many cases, we directly quote sections of published work. Mention of trade names or commercial products is solely for the purpose of providing specific information and does not imply recommendation or endorsement by IVCC or its funders.