Download the Tech Updates highlighting vector biology and control news, publications and resources.

Given the breadth of vector control-related literature, we are unable to include all relevant work. These updates are intended to focus primarily on Anopheles biology and a subset of control topics with global relevance.

Any views expressed in the updates do not necessarily reflect the views or opinions of IVCC. In many cases, we directly quote sections of published work. Mention of trade names or commercial products is solely for the purpose of providing specific information and does not imply recommendation or endorsement by IVCC or its funders.

IVCC has the pleasure of announcing that, following a meeting of the South African National Accreditation System (SANAS) Approval Committee in June 2021, the Ifakara Health Institute’s (IHI) trials facility, headquartered in Bagamoyo, Tanzania, has been granted Good Laboratory Practice (GLP) certification. This facility is internationally recognised for its expertise in testing new vector control products for industry, product development partnerships, and generates data for regulatory submissions, including WHO Prequalification evaluations.

Since 2016, IVCC has been supporting the IHI trials facility towards GLP certification with funding from the Bill & Melinda Gates Foundation. Support was provided for the GLP certification process and to make the essential infrastructure improvements required for full GLP compliance. In addition, training was provided to key staff through participation in GLP workshops and specialist courses in quality assurance and data management systems. Ongoing mentoring was provided by the GLP project team on quality management system development, including the development of Standard Operating Procedures (SOPs) and on-site facility audits were conducted to provide information on progress of the facility towards becoming fully GLP compliant.

IVCC congratulates Sarah Moore, who leads the IHI test facility, Jason Moore (test facility manager), Emmanuel Mbuba (GLP coordinator) and all of the facility staff on this wonderful achievement.

Recent semi-field results from Project BITE under IVCC’s Indo-Pacific Initiative (IPI) have shown that forest packs containing bite prevention tools could have an impact on public health beyond just personal protection. The results come from trials that UCSF-Malaria Elimination Initiative, IVCC’s lead partner on BITE, conducted at AFRIMS (Armed Forces Research Institute of Medical Sciences) and Kasetsart University in Thailand.

Project BITE aims to evaluate the effectiveness of forest packs containing a spatial emanator, topical repellent and insecticide-treated clothing when deployed to forest dwellers, goers and rangers in the Greater Mekong Subregion. The project comprises semi-field trials in Thailand and field trials in Cambodia. The trials conducted at the two sites in Thailand measured the protective efficacy of the products using the following endpoints: landing inhibition, knockdown, delayed mortality at 24 hours and blood feeding inhibition.

The semi-field findings demonstrated that these products not only prevent mosquitoes from landing but can also kill or delay them from seeking another host, thus preventing diversion of mosquitoes to nearby non-users of the tools. Delaying host-seeking and feeding inhibition also could have an additional impact on vectorial capacity by reducing human biting rate (HBR) and the vectors’ lifetime reproductive output.

Following the semi-field trials, a formative assessment is now underway in Mondulkiri province in Cambodia, looking at user acceptability of the products. A field entomology trial will take place in Q3-Q4 2021, and a field epidemiological trial will commence in Q1 2022, both at the same sites in Mondulkiri, which will test the hypotheses coming out of the semi-field results.

IVCC and its partners are hopeful that the evidence generated by BITE will help make the case to national programmes and donors on the effectiveness of forest packs in the fight against outdoor malaria transmission amongst at-risk groups – both in Asia-Pacific and beyond.