Last week, indoor residual spraying began in Papua New Guinea (PNG) as part of a 12-month epidemiological field trial under the NATNAT project led by PNG Institute of Medical Research, PNG National Malaria Control Programme, Burnet Institute, James Cook University and Rotarians Against Malaria (RAM).

The trial is running in 4 villages- Wasab, Bulal, Megiar and Mirap- in the north coast province of Madang, and will assess the effectiveness, feasibility, community acceptability and cost-effectiveness of residual spraying of household structures. The study is designed as an interrupted time series with two interventions over the time period and two control villages.

The trial is part of NATNAT’s wider programme of activity in PNG which aims to develop an evidence-based framework for the rapid assessment and adoption of novel vector control tools (VCTs) and has 4 main objectives:

• Strengthen laboratory, semi-field and field capacity to test new VCTs
• Conduct rigorous field evaluations of new VCTs and implementation (IRS, larval source management and spatial emanators)
• Investigate the community and health system acceptability and cost-effectiveness of new VCTs
• Support a national malaria control programme (NMCP)-led formal network for vector control tools and interventions in PNG

Malaria rates are increasing in PNG and elsewhere in Melanesia.  LLINs are necessary but will not be sufficient on their own to reverse this trend and move towards elimination. Recent studies have also shown a decline in the effectiveness of LLINs in PNG and -in some areas- low net usage two years after mass distribution. Coupled with the challenge of early, outdoor- biting mosquitoes, new tools and improved usage are needed to fill these gaps.

NATNAT is part of IVCC’s Indo-Pacific Initiative (IPI) which is building on experience of vector control innovation in sub-Saharan African to identify and scale-up use of new and existing tools to support malaria control and elimination in the Indo-Pacific.   IVCC is facilitating direct dialogue between its Africa-based staff and the NATNAT team to provide lessons learned and best practice with implementation planning and training of spray operators, based on years of field experience.

IPI also complements IVCC’s focus on Africa through contributing to evidence on the performance of outdoor tools for use in last-mile elimination scenarios, as well as expanding the markets for other novel products such as 3^rd generation IRS.

NATNAT is one of three projects IVCC is leading in the Indo-Pacific region, funded by Australia Aid as part of its Global Health Security Initiative. The other two projects are Project BITE and a mathematical modelling project to predict the impact of new tools in the region.

Considering the significant challenges caused by COVID-19, IVCC commends its NATNAT partners for achieving this milestone on the road towards a possible reintroduction of national IRS spraying in PNG.

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IVCC has the pleasure of announcing that, following a meeting of the South African National Accreditation System (SANAS) Approval Committee in June 2021, the Ifakara Health Institute’s (IHI) trials facility, headquartered in Bagamoyo, Tanzania, has been granted Good Laboratory Practice (GLP) certification. This facility is internationally recognised for its expertise in testing new vector control products for industry, product development partnerships, and generates data for regulatory submissions, including WHO Prequalification evaluations.

Since 2016, IVCC has been supporting the IHI trials facility towards GLP certification with funding from the Bill & Melinda Gates Foundation. Support was provided for the GLP certification process and to make the essential infrastructure improvements required for full GLP compliance. In addition, training was provided to key staff through participation in GLP workshops and specialist courses in quality assurance and data management systems. Ongoing mentoring was provided by the GLP project team on quality management system development, including the development of Standard Operating Procedures (SOPs) and on-site facility audits were conducted to provide information on progress of the facility towards becoming fully GLP compliant.

IVCC congratulates Sarah Moore, who leads the IHI test facility, Jason Moore (test facility manager), Emmanuel Mbuba (GLP coordinator) and all of the facility staff on this wonderful achievement.