Along with our colleagues from Malaria No More UK, GSK, Jenner Institute and Medicines for Malaria Venture, IVCC is proud to have contributed to a letter in the New Statesman, which sets out how the UK can end malaria & help save millions of lives.

The piece highlights how maintaining momentum is a challenge in the face of a storm of competing global priorities and health challenges. But advances in game-changing new tools such as next-generation insecticide treated nets (ITNs) and malaria vaccines mean malaria can and will be consigned to the history books in our lifetimes .

For the greatest impact, interventions must be combined with other interventions as part of a toolbox approach. Dual active ingredient ITNs, for example, adapted to overcome mosquito resistance, have protected more than 60 million people and are one of a number of ways of reducing the impact of mosquitos themselves.

Read the full op-ed here: https://www.newstatesman.com/spotlight/healthcare/public-health/2024/04/uk-scientists-malaria-disease-public-health-malaria-no-more

IVCC was delighted to welcome a delegation from the Labour Party, including Kim Johnson MP, Paula Barker MP, and Dr Zubir Ahmed a Labour PPC to Liverpool to meet representatives from IVCC and the Liverpool School of Tropical Medicine (LSTM).

Accompanied by Astrid Bonfield, CEO of Malaria No More UK and Anyika Onuora, Olympic athlete and Malaria No More UK ambassador and staff from both LSTM and IVCC, the Labour Party delegation heard about the innovative vector control pipeline that IVCC is developing. For example, the impact of IVCC’s long held strategic aim to bring new active ingredients (AIs) to the insecticide-treated net (ITN) market was highlighted by the evidence and policy endorsement of BASF’s Interceptor® G2.

The group also heard about evidence developed on the efficacy of outdoor tools by Project Bite Interruption Toward Elimination (BITE) and Newly Adapted Tools Network Against vector-borne disease Transmission (NATNAT) has enhanced the evidence base for these new product categories, through the Indo-Pacific Initiative (IPI.

These, and other success storied, showcased the importance of collaborative working and how the commitment of our partners from industry, academia, the public sector, and advocacy, make life-saving vector control possible.

The guests also visited the Liverpool Insect Testing Establishment (LITE) which supports the testing of insecticide-based products for commercial partners against insecticide-resistant colonies.  LITE maintains a range of insecticide susceptible and resistant colonies of mosquitoes and provides a range of approaches for insecticide efficacy testing. The guests closed the day with a visit to LSTM’s venom unit which houses the largest and most diverse collection of tropical venomous snakes in the UK and leads pioneering research into a universal anti-venom and improvements in the efficacy, affordability and safety of snakebite treatments.

Photo caption: The delegation poses at the entrance of the LSTM buildings.

From left to right: David Lalloo (LSTM Director), Paula Barker MP, Dr Zubir Ahmed, Astrid Bonfield (Malaria No More UK CEO), Anyika Onuora, Professor Martin James Donnelly (Head of Vector Biology Department, LSTM), Justin McBeath (IVCC CEO) and Kim Johnson MP.

Credit: LSTM/ Alejandra Cardona-Mayorga

At a series of events in late September and early October, Malaria No More UK brought together leading scientists, innovators and policymakers to celebrate the work and role of science and innovation in the global fight against malaria.

First, IVCC attended a networking reception at this year’s Conservative Party Conference (Manchester, 1st to 4th October 2023). During the event, IVCC engaged in conversations with Andrew Mitchell (MP), Minister of State for Development and Africa, and Astrid Bonfield, CEO of Malaria No More UK. IVCC emphasized the critical importance of vector control innovation and product development partnerships. These collaborations are essential in addressing the emerging threat of insecticide resistance, which is reducing the efficacy of established tools.

The following week, IVCC CEO Justin MacBeath participated in roundtable event discussion the future of global health. Against the backdrop of the Labour Party Conference (Liverpool, 8^th to 11^th October) Malaria No More UK convened Labour MPs, Labour candidates, academics, scientists, and industry representatives. Justin highlighted the crucial role of Product Development Partnerships in creating new vector control tools and ensuring fair access for vulnerable populations.

It was followed by Global Health Networking Reception, hosted by STOPAIDS and Malaria No More UK. Virendra Sharma (MP) opened the event, alongside Astrid Bonfield who showcased the Finish the Job campaign: urging decision makers to commit to ending malaria in our lifetimes. Anyika Onoura, Team BG World & Olympic medallist, shared her experience of falling ill with malaria ahead of the 2016 Rio Olympics and emphasized the need for ongoing investment to end malaria.

IVCC CEO, Justin MacBeath at the Malaria No More UK Labour Party Conference breakfast roundtable. Image credit: Malaria No More UK.

From left to right: Catherine West (MP), Anyika Onoura and Virendra Sharma (MP) at the Global Health Networking Reception. Image credit: Malaria No More UK.

Progress against malaria continues to stall, according to the 2023 World Malaria Report, published today by the World Health Organization (WHO).

Despite the efforts of malaria-endemic countries and their partners, the world is worse off now than before the COVID pandemic both in terms of number of malaria cases and deaths.

The combination of limited resources, challenges such as drug and insecticide resistance, socioeconomic constraints, humanitarian crises, and climate-driven extreme weather events creates a challenging landscape for malaria elimination. If current trajectories continue, the goal of reducing malaria cases to 6.0 cases per 1000 population by 2030 will be missed by 89%.

The WHO report emphasises the importance of developing more efficacious tools to accelerate progress toward the global malaria targets. Interrupting the transmission cycle to reduce the spread of malaria is key to that aim.

At IVCC, in partnership with our stakeholders, we are committed to delivering a sustainable toolbox of vector control solutions that address the evolving challenges in vector control and malaria elimination.

Insecticide-treated nets continue to be the primary vector control tool used in most endemic countries. Over 254 million nets were distributed in 2022, up by 34 million compared to 2021.

A longstanding collaboration between BASF and IVCC to deliver a next generation active ingredient treated net formulation has been an important step in the fight against insecticide resistant mosquitoes.

Interceptor® G2, combines a pyrethroid (alphacypermethrin) with a new-to-public-health active ingredient, a pyrrole (chlorfenapyr), which represents a novel mode of action in vector control. In March 2023, the WHO strongly recommended the deployment of such nets in areas where mosquitoes have become resistant to pyrethroids.

This milestone is testament to the importance of product development partnerships to deliver high-impact, cost-effective prevention tools, adapted to the needs of endemic countries.

Despite the success of interventions such as the Interceptor® G2, global investment in overall malaria research and product development dropped by US$ 603 million in 2022 – its lowest recorded level in the past 15 years, and down by over 10% compared with 2021.

Climate change is also having a dramatic impact on malaria transmission and burden. The effects are seen in the gradual extension of the transmission range and seasonality of malaria, and an increase in the number of extreme weather events.

IVCC recognises the need for innovative tools to reach the most vulnerable populations especially in settings where ITNs and traditional indoor residual spraying (IRS) for fixed structures might not be practical.

We are working with partners to accelerate the availability of solutions that address these challenges, such as new tools which address outdoor biting or outdoor transmission.

The funding gap between the amount invested in malaria control and elimination continues to widen. With a shortfall of UD$ 3.7 billion in 2022, funding availability to support innovation, roll out of existing tools and the cost of procurement and delivery is increasingly uncertain.

This scenario, coupled with a global economy seeing ever-increasing costs for raw materials and logistics, means IVCC remains committed to exploring innovative strategies to expand the availability of cost-effective life-saving vector control tools. IVCC recognises the need for greater emphasis and recognition of country input into this ambition and makes sure that the considerations of malaria programmes are incorporated in all aspects of product development and distribution.

IVCC believes that it is only through partnerships, which take into account local needs, that vector control implementation can be expanded beyond the scope of donor-supported programmes and lead to the establishment of sustainable capacity.

The World Malaria Report, published annually, provides a comprehensive and up-to-date assessment of trends in malaria control and elimination across the globe. This year’s report includes, for the first time, a dedicated chapter focused on the intersection between climate change and malaria.

Find out more in this year’s World Malaria Report.